Midtrimester amniyotik sıvı leptin ve insülin düzeyleri ile gestasyonel diabetes mellitus ilişkisi Midtrimester amniotic fluid leptin and insulin levels and their relation with gestational diabetes mellitus

Aim. The aim of this study is to investigate whether amniotic fluid leptin and insulin levels can be used for prediction of for prediction of gestational diabetes mellitus or not. Methods. The levels of leptin and insulin were measured in the samples of amniotic fluid which were obtained at 16-20 weeks of pregnancy during genetic amniocentesis. We recorded the patients who developed gestational diabetes mellitus and who had healthy gestation. Results. Amniotic fluid leptin (17.3 ng/mL) and insulin (3.4 ng/mL) levels were significantly increased in gestational diabetes mellitus group as compared to control group’s amniotic fluid leptin (10.1 ng/mL) and amniotic fluid insülin (1.7 mg/mL) levels. Conclusion. Increased levels of amniotic fluid leptin and insulin levels before gestational diabetes mellitus symptoms gives the idea that these proteins can be used as predictors for gestational diabetes mellitus.